Die meisten Texte und Bilder haben als Basis die eigene Forschung, die z.B. im Abschnitt Publikatonenen aufgeführt ist. Einige Ideen und Deutungen sind unabhängig bzw. parallel von anderen Gruppen entstanden, haben es jedoch nicht immer bis zu einer eigenen Veröffenlichung geschaft. Die unten aufgeführten Referenzen sind daher nicht immer die Grundlage für Inhalte sondern dienen teilweise auch zur Vertiefung. (Die meisten wissenschaftlichen Veröffentlichungen sind in englischer Sprache abgefasst.)

vor 1960

  • Claude, A. (1940): Particulate components of normal and tumor cells, Science 91(2351); 77–78;  PMID 17783332; doi: –> 10.1126/science.91.2351.77
  • J.D. Watson and F.H.C. Crick (1953): A Structure for Deoxyribose Nucleic Acid, Nature, 171; –> PDF
  • Palade, GE. (1955): A small particulate component of the cytoplasm , J Biophys Biochem Cytol . 1(1); 59–68; –> PMID 14381428; –> PDF (open access)
  • McQuillen, K., Roberts, RB. und Britten, RJ. (1959): SYNTHESIS OF NASCENT PROTEIN BY RIBOSOMES IN ESCHERICHIA COLI, Proc Natl Acad Sci USA 45(9):1437–1447; –> PMID 16590524; –> PDF (open access)











F. Schluenzen*, A. Tocilj*, R. Zarivach, J. Harms, M. Gluehmann, D. Janell, A. Bashan, H.
Bartels, I. Agmon, F. Franceschi & A. Yonath. Structure of a functionally activated small
ribosomal subunit at 3.3 A resolution. –> Cell, 102, 615-623 (2000).


M. Pioletti*, F. Schluenzen*, J. Harms*, M. Gluehmann, R. Zarivach, A. Bashan, H. Bartels, T.
Auerbach, F. Franceschi and A.Yonath. The crystal structure of complexes of the small
ribosomal subunit with tetracycline, edeine and IF3. –> EMBO J., 20, 1829-1839 (2001).

J. Harms*, F. Schluenzen*, R. Zarivach*, A. Bashan, S. Gat, I. Agmon, H. Bartels, F.
Franceschi & A. Yonath, High resolution structure of the large ribosomal subunit from a
mesophilic eubacterium. Cell, 107, 679-688 (2001).

F. Schluenzen*, R. Zarivach*, J. Harms*, A. Bashan, A. Tocilj, R. Albrecht, A. Yonath and F.
Franceschi, Structural basis for the interaction of antibiotics with the peptidyl transferase
center in eubacteria. Nature, 413, 814-821 (2001).


D.E. Brodersen, W.M. Clemons, A.P. Carter, B.T. Wimberley, V. Ramakrishnan. Crystal Structure of the 30S Ribosomal Subunit from Thermus thermophilus: Structure of the Proteins and their Interactions with 16S RNA. JMB 316, 725-768, 2002. ( PDF –>Venky Ramakrishnans pages)


Bashan, I. Agmon, R. Zarivach, F. Schluenzen, J. Harms, R. Berisio, H. Bartels, F.
Franceschi, T. Auerbach, H.A.S. Hansen, E. Kossoy, M. Kessler and A. Yonath, Structural
basis of the ribosomal machinery for peptide bond formation, translocation, and nascent chain
progression, Mol Cell, 11, 91-102 (2003).

F. Schluenzen*, J.M. Harms*, F. Franceschi, H. A.S. Hansen, H. Bartels, R. Zarivach and A.
Yonath, Structural basis for the antibiotic activity of ketolides and azalides, Structure, 11, 329-
38 (2003).

 # J.M. Harms, H. Bartels, F. Schluenzen, and A. Yonath, Antibiotics acting on the
translational machinery, J Cell Sci, 116, 1391-93 (2003). Poster Illustration: JMH.

 R. Berisio, F. Schluenzen, J. Harms, A. Bashan, T. Auerbach, D. Baram and A. Yonath,
Structural insight into the role of the ribosomal tunnel in cellular regulation, Nat Struct Biol, 10,
366-70 (2003).

Berisio, J. Harms, F. Schluenzen, R. Zarivach, H. A.S. Hansen, P. Fucini and A. Yonath,Structural insight into the antibiotic action of telithromycin on resistant mutants, J. Bacteriol, 185, 4276-9 (2003).


M. Harms*, F. Schlünzen*, P. Fucini, H. Bartels and A.E. Yonath, Alterations at the petidyl transferase centre of the ribosome induced by the synergistic action of the streptogramins dalfopristin and quinupristin. BMC Biology, 2:4 (2004).

F. Schlünzen, E. Pyetan, P. Fucini, A. Yonath and J.M. Harms, Inhibition of Peptide Bond Formation by Pleuromutilins: the Structure of the 50S Ribosomal Subunit from Deinococcus radiodurans in Complex with Tiamulin, Molecular Microbiology, Mol. Microbiology, 54(5), 1287-1294 (2004).

D. N. Wilson*, F. Schluenzen*, J.M. Harms*, R. Albrecht, J. Buerger, T. Yoshida, T. Ohkubo, Y. Kobayashi and P. Fucini. The ribosome recycling factor interacts exclusively with ribosomal elements associated with tRNA binding and translocation, EMBO J. 24: 251-260 (2005); advance online publication, December 23, 2004.


# M. Amit, R. Berisio, D. Baram, J. Harms, A. Bashan and A. Yonath. A crevice adjoining the ribosome tunnel: Hints for cotranslational folding, FEBS Lett. 2005 Jun 13;579(15):3207-13. Epub 2005 Mar 23

M. Diaconu, U. Kothe, F. Schlünzen, N. Fischer, J.M. Harms, A.G. Tonevitski, H. Stark, M.V. Rodnina and M.C. Wahl. Structural Basis for the Function of the Ribosomal L12 Stalk in Factor Binding and Activation of GTP Hydrolysis, Cell. Jul 1;121(7):991-1004 (2005).

Schlünzen F., Wilson DN., Tian P, Harms JM, McInnes S, Hansen H, Albrecht R, Buerger J, Wilbanks S, Fucini P. The binding mode of the trigger factor on the ribosome: implications for protein folding and SRP interaction. Structure (Camb). 2005 Nov;13(11):1685-94.

# Wilson DN, Harms JM, Nierhaus KH, Schlünzen F and Fucini P. Species-specific antibiotic-ribosome interactions: implications for drug development. Biological Chemistry, 386, 12, Dec. 2005. (cover illustration: J.M. Harms)


Schluenzen F, Takemoto C, Wilson DN, Kaminishi T, Harms JM, Hanawa-Suetsugu K, Szaflarski W, Kawazoe M, Shirouzu M, Nierhaus KH, Yokoyama S, Fucini P. The antibiotic kasugamycin mimics mRNA nucleotides to destabilize tRNA binding and inhibit canonical translation initiation. Nat Struct Mol Biol. 2006 Oct;13(10):871-8. Epub 2006 Sep 24. (cover illustration idea: JM. Harms, DN. Wilson)


Kaminishi T.*, Wilson DN.*, Takemoto C.*, Harms JM.*, Kawazoe M., Schluenzen F., Hanawa-Suetsugu K., Shirouzu M., Fucini P. and Yokoyama S. A snapshot of the 30S ribosomal subunit capturing mRNA via the Shine-Dalgarno interaction. Structure. 2007 Mar;15(3):289-97. (cover illustration: JM. Harms)


# F. Van Bambeke, JM. Harms, Y. Van Laethem, and PM. Tulkens. Ketolides: pharmacological profile and rational positioning in the treatment of respiratory tract infections. Expert Opin Pharmacother. 2008 Feb;9(2):267-283 (2008)

JM. Harms*, DN. Wilson*, F. Schluenzen*, S. Connell, T. Stachelhaus, Z. Zaborowska, C. Spahn, P. Fucini. Translational regulation via L11: Molecular switches on the ribosome turned on and off by thiostrepton and micrococcin. Molecular Cell, 2008, 30(1):26-38 (cover illustration: JM. Harms)

DN. Wilson*, F. Schluenzen*, JM. Harms*, AL. Starosta, SR. Connell, and P. Fucini. The oxazolidinone antibiotics perturb the ribosomal peptidyl-transferase center and effect tRNA positioning. PNAS, online 29.Aug.2008. Print: September 9, 2008 vol. 105 no. 36 13339-13344


# D. Sohmen, JM. Harms, F. Schluenzen and DN. Wilson. Snapshot: Antibiotic Inhibition of Protein Biosynthesis, Part 1. Cell 138(6) pp. 1248 – 1248.e1 (2009)

# D. Sohmen, JM. Harms, F. Schluenzen and DN. Wilson. Snapshot: Antibiotic Inhibition of Protein Biosynthesis, Part 2. Cell 139(1) pp. 212 – 212.e1 (2009)

# JM. Harms, F. Schluenzen. Nobelpreis für Chemie. Naturwissenschaftliche Rundschau, 12, 2009. (cover illustration: JM. Harms)

nach 2010

# F. Schluenzen, JM. Harms, Die Struktur des Ribosoms – die Eiweißfabrik im atomaren Detail. Physik in unserer Zeit, 01, 2011.